/* Font family */

@import url('https://fonts.googleapis.com/css?family=Tajawal:500');

/* SCROLLBAR for Chrome -webkit- */

.msa-container ::-webkit-scrollbar {
    height: 15px;
}

.msa-container ::-webkit-scrollbar-track {
    background: #EEE;
}

.msa-container ::-webkit-scrollbar-thumb {
    width: 450px !important;
    background: #1976D2;
    border-radius: 55px;
}

.msa-container {
    resize: horizontal;
    position: relative;
    width: 100%;
    height: auto;
    min-height: 313px;
    overflow: hidden;
}

.sequence-length {
    position: relative;
    margin: 1.75em 0;
    height: 1em;
    background: #ccc;
}

.annotation {
    display: flex;
    position: absolute;
    top: -0.7em;
    height: 2em;
    color: #fff;
    background: #CCC;
    font-family: 'Tajawal', sans-serif !important;
    font-size: 1.2em;
    justify-content: center;
    /*text-align */
    align-items: center;
    /* vertical-align */
    cursor: pointer !important;
}


/* Dashes at the end of the annotations */

.annotation::before {
    position: absolute;
    top: 40px;
    content: "";
    width: 100%;
    height: 78px;
    box-sizing: border-box;
    border-left: 3px solid #a3a3a3;
    border-right: 3px solid #a3a3a3;
    border-style: dotted;
    background: none;
    z-index: -1;
    overflow: hidden;
}

.annotation>p {
    font-size: 18px;
    text-align: center;
    max-width: 100%;
}


/*  Shadow for particular annotation on protein sequences 
    && if you change the height or width of aminoacids , do not forget to set that height 
.annotation::after {
  position: absolute;
  top: 135px;
  content: "";
  width: 100%;
  height: 288px; 
  background: #111;
  z-index: -1;
} */

.sequence-length a:nth-child(1) .annotation {
    background: #4285F4;
    border-bottom-right-radius: 50px;
    border-top-right-radius: 50px;
}

.sequence-length a:nth-child(2) .annotation {
    background: #EA4335;
    border-radius: 20px;
}

.sequence-length a:nth-child(3) .annotation {
    background: #FBBC05;
    border-bottom-left-radius: 20px;
    border-top-right-radius: 20px;
}

.sequence-length a:nth-child(4) .annotation {
    background: #34A853;
    border-radius: 0px;
}

.sequence-length a:nth-child(5) .annotation {
    background: #7B0099;
    border-top-left-radius: 20px;
    border-bottom-right-radius: 20px;
}

.sequence-length a:nth-child(6) .annotation {
    background: #004883;
    border-bottom-left-radius: 20px;
    border-top-left-radius: 20px;
}

.sequence-length a:nth-child(7) .annotation {
    background: #FF5722;
    border-bottom-left-radius: 20px;
    border-top-left-radius: 20px;
}

.sequence-length a:nth-child(8) .annotation {
    background: #4285F4;
    border-bottom-right-radius: 50px;
    border-top-right-radius: 50px;
}

.sequence-length a:nth-child(9) .annotation {
    background: #EA4335;
    border-radius: 20px;
}

.sequence-length a:nth-child(10) .annotation {
    background: #34A853;
    border-radius: 0px;
}

.sequence-length a:nth-child(11) .annotation {
    background: #FBBC05;
    border-bottom-left-radius: 20px;
    border-top-right-radius: 20px;
}

.sequence-length a:nth-child(12) .annotation {
    background: #7B0099;
    border-top-left-radius: 20px;
    border-bottom-right-radius: 20px;
}

.sequence-length a:nth-child(13) .annotation {
    background: #004883;
    border-bottom-left-radius: 20px;
    border-top-left-radius: 20px;
}

.sequence-length a:nth-child(14) .annotation {
    background: #FF5722;
    border-bottom-left-radius: 20px;
    border-top-left-radius: 20px;
}

.msa-container .annotation>a,
.msa-container a:link,
.msa-container a:visited,
.msa-container a:hover,
.msa-container a:focus {
    text-decoration: none;
    font-size: 14px;
    color: #FFF;
}

.msa-container .annotation_start_point {
    position: absolute;
    left: 5px
}

.msa-container .annotation_end_point {
    position: absolute;
    right: 5px;
}

.msa-container .sequence-container {
    position: relative;
    margin-left: 160px
}

.msa-container .sequence-container section
/* or .protein */

{
    display: flex;
    flex-flow: row nowrap;
}

.msa-container .sequence-container section div {
    min-width: 20px;
    min-height: 20px;
    background: #fff;
    /* border: 1px solid #fff;  if you open it; do not forget to set height and width as 20px. Same for specieNames */
    color: #fff;
    line-height: 20px;
    font-size: 13px;
    text-align: center;
    font-family: sans-serif !important;
    cursor: default;
    position: absolute;
    top: 0;
}


/* Domain and Sequence Parts */

.msa-container .annotation-sequence {
    position: relative;
    left: 162px;
}

.msa-container .species-and-gene-names {
    position: absolute;
    top: 0;
    left: 0;
    z-index: 150;
    background: #fff;
    font-style: italic;
    float: left;
}

.msa-container .gene-name:first-of-type {
    margin-top: 1.4em;
}

.msa-container .species-and-gene-names>div:nth-last-of-type(2) {
    margin-bottom: 1.35em!important;
}

.msa-container .gene-name {
    /*position: absolute;*/
    /*left: 2px;*/
    margin: 1em 0;
    margin-bottom: 1em;
    /*top: 40px;*/
    height: 1.75em;
    width: 158px;
    background: #1976D2;
    border-radius: 50px;
    text-align: center;
    line-height: 1.8;
    color: #fff;
    font-family: 'Tajawal', sans-serif !important;
    font-style: italic;
    padding-top: 0em;
    cursor: default;
}

.msa-container .species-names {
    margin-top: 42px;
    cursor: pointer;
    font-style: italic;
}

.msa-container .species-name {
    min-height: 20px;
    max-height: 20px;
    /* border: 1px solid #fff; if you open it; do not forget to set height and width as 20px. Same for specieNames */
    font-family: 'Tajawal', sans-serif !important;
    line-height: 18px;
    padding-left: 10px;
    /* z-index: 1 !important; */
    min-width: 150px !important;
    max-width: 150px !important;
    background: #2a76d2 !important;
}

.msa-container .species-name a {
    color: #FFF !important;
    font-size: 14px;
}

.msa-container .species-name .hiding-button {
    padding: 0px 5px;
    text-align: center;
    /*border: 2px solid #FFF;*/
    border-radius: 50%;
    margin-right: 5px;
    font-weight: bold;
}

.msa-container .species-name .hiding-button:hover {
    background: #FFF !important;
    color: #2a76d2 !important;
}


/* Specific Amino acids for alterations */

.specialAa {
    cursor: pointer !important;
    border-radius: 40%;
    border-color: transparent !important;
    box-shadow: 0 0 7px #000;
}

.highlighter-container {
    width: 100%;
    height: 20px;
    position: relative;
    margin-left: 160px;
}

.highlighter-container>div {
    position: absolute;
}

.highlighter-container .modification {
    font-size: 22px;
    font-weight: bold;
    color: red;
}

.modification-highlighted:before {
    margin-top: -30px !important;
}

.aminoacid-info {
    color: #333;
    font-family: 'Tajawal', sans-serif !important;
    font-size: 12px;
}


/*SCROLL ISLEMI OLMADAN .aminoacid-info div */

.variation-text-box {
    position: absolute;
    display: flex;
    z-index: 999999;
    justify-content: center;
    align-items: center;
    width: 300px;
    min-height: 150px;
    height: auto;
    background: #fff;
    opacity: .96;
    border-radius: 3px;
    font-size: 18px !important;
}

.variation-inner-text-box {
    height: 140px !important;
    max-height: 140px !important;
    padding: 10px !important;
    overflow-y: scroll;
    width: 100%;
    overflow-x: hidden;
}

.msa-container .variation-inner-text-box a {
    color: #004883;
}

.variation-inner-text-box h3 {
    margin-top: 1em;
    margin-bottom: 0;
    padding: 0;
    font-weight: bold
}

.variation-inner-text-box h3:nth-of-type(1) {
    margin-top: 0;
}

.aminoacid-info>div::after {
    content: "";
    position: absolute;
    top: 14px;
    left: -10px;
    width: 20px;
    height: 20px;
    background: inherit;
    z-index: -1;
    transform: rotateZ(45deg);
}


/*  In order to distinguish the sequence of Homo sapiens */

.variation-text-box.rightArrow::after {
    right: -10px;
    left: auto!important;
}

.sequence {
    position: relative;
    height: 20px;
    background: url("data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAABQAAAAUCAAAAACo4kLRAAAAAW9yTlQBz6J3mgAAABpJREFUGNNjiMECGIaY4PT///8fGFxOoqYgACNCkklBjzWtAAAAAElFTkSuQmCC") repeat-x;
    width: 100%;
}

.sequence>div {
    cursor: pointer!important;
}

.highlight-column {
    border-left: 2px solid #fff!important;
    border-right: 2px solid #fff!important;
    z-index: 1231!important;
    border-radius: 0!important;
}

.bottom-panel {
    padding: 0 5px;
    width: 100%;
}

.highlight-column {
    border-left: 2px solid #fff!important;
    border-right: 2px solid #fff!important;
    z-index: 1231!important;
    border-radius: 0!important;
}

.position-number {
    position: absolute;
    top: -20px!important;
    color: #000!important;
}

.go-to-position {
    display: block;
    float: left;
    margin-left: 5px
}

.msa-button {
    position: relative;
    background: #4285F4;
    color: #FFF;
    border-radius: 10px;
    padding: 5px;
    margin: 12px;
    float: left;
    display: block;
}


/* Form CSS */

.form_input {
    margin: 15px 1px;
    height: 15px;
    width: 40px;
    font-size: 15px;
    font-weight: bold;
    color: #555;
    border: 1px solid #555;
    outline: none;
    padding-left: 3px;
    text-align: center;
    border-radius: 30px;
}

.form_input::-webkit-input-placeholder {
    font-size: 15px;
    color: #555;
    opacity: 1;
}

.form_input::-moz-placeholder {
    font-size: 15px;
    color: #555;
    opacity: 1;
}

.form_input:-ms-input-placeholder {
    font-size: 15px;
    color: #555;
    opacity: 1;
}

.form_input:-moz-placeholder {
    font-size: 15px;
    color: #555;
    opacity: 1;
}


/* Tooltips */

.tooltip {
    position: relative;
    /* display: inline-block; */
    overflow: visible!important;
}


/* Tooltip text */

.tooltip .tooltiptext {
    visibility: hidden;
    min-width: 130px;
    background-color: #fff;
    color: #555;
    text-align: center;
    padding: 5px 5px;
    border-radius: 6px;
    /* Position the tooltip text */
    position: absolute;
    z-index: 32123132123123 !important;
    border: 1px solid #ccc;
    top: -5px;
    left: 105%;
    margin-left: -60px;
    opacity: 0;
    transition: opacity 0.3s;
}

.tooltip:hover .tooltiptext {
    visibility: visible;
    opacity: 1;
}


/* Tooltip arrow */

.tooltip .tooltiptext::after {
    content: " ";
    position: absolute;
    top: 50%;
    right: 100%;
    margin-top: -5px;
    border-width: 5px;
    border-style: solid;
    border-color: transparent #fff transparent transparent;
}

.reset-button {
    display: block;
    background: #1ab357;
    color: #FFF;
    float: right;
    margin: 10px;
    border-radius: 3px;
    padding: 5px;
}

.scroll-container {
    position: relative;
    overflow: scroll;
    max-height: 350px;
    padding-bottom: 0.4em;
}